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HC Technology
Butylparaben
Categories:
Pharmaceutical Excipients

Butylparaben

Alias
Butyl p-hydroxybenzoate / Butyl 4-hydroxybenzoate / 4-Hydroxybenzoic acid butyl ester / Nipabutyl / Butylparaben (pharmacopoeia)
CAS No.
Molecular Formula
C11H14O3
Structure
Butylparaben Chemical Structure
Product Details

Product Overview

Usage

Used as an antimicrobial preservative in pharmaceutical excipients. Among the parabens homologs, it exhibits the strongest bacteriostatic activity and the best oil solubility, with excellent inhibitory effects against molds, yeasts and certain bacteria. Widely applied in topical ointments, creams, gels and suppositories, especially semi-solid preparations with oily bases. Often combined with other parabens (such as methylparaben and propylparaben) to balance water solubility and antimicrobial efficacy, broadening the antimicrobial spectrum.
Specifications

Technical Specifications

Appearance White or off-white crystals or crystalline powder
Content (on dried basis) 98.0%–102.0%
Melting point 68–71℃
Acidity Compliant (0.1 mol/L NaOH consumption ≤0.1 mL)
Solution clarity and color Clear and colorless
Chloride (Cl) ≤0.035%
Sulfate (as SO₄) ≤0.024%
Related substances Individual impurity ≤0.4%, total impurities ≤0.8%
Loss on drying ≤0.5% (silica gel desiccator, vacuum dried to constant weight)
Residue on ignition ≤0.1%
Heavy metals ≤20 ppm
Arsenic ≤0.0002%
Logistics

Packaging, Storage & Transport

Packaging

25 kg fiber drum, double polyethylene liner

Storage

Store tightly closed in a cool, dry, well-ventilated place

Transport

Transport as general chemicals; protect from moisture, sunlight and physical damage; keep packaging intact